Synlett

A Novel Protocol for Construction of Indolylmethyl Group at Aldehydes or Ketones

H Tokuyama, M Watanabe, Y Hayashi, T Kurokawa…

Index: Tokuyama; Watanabe; Hayashi; Kurokawa; Peng; Fukuyama Synlett, 2001 , # 9 p. 1403 - 1406

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Citation Number: 22

Abstract

Abstract: A new method for introduction of indolylmethyl group to aldehydes or ketones using diethyl (o-isocyanophenylmethyl) phosphonate through Horner-Wadsworth-Emmons condensation, thiolmediated radical cyclization, and the subsequent desulfurization is described. The Horner-Wadsworth-Emmons reagent was prepared from 2- nitrobenzaldehyde in a concise three-step sequence. Key words: 3-substituted indoles, ...

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Discovery of novel phosphonic acid derivatives as new chemic...

[Matsui, Toshiaki; Takahashi, Shinya; Matsunaga, Naoki; Nakamura, Kazunori; Omawari, Nagashige; Sakai, Masaru; Kamoshima, Wataru; Terai, Kouichiro; Ohno, Hiroyuki; Obata, Takaaki; Nakai, Hisao; Toda, Masaaki Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 12 p. 3807 - 3815]

Une nouvelle voie d'acces aux indoles par condensation ylure...

[Corre, M. Le; Hercouet, A.; Stanc, Y. Le; Baron, H. Le Tetrahedron, 1985 , vol. 41, # 22 p. 5313 - 5320]

Exploration of N-phosphonoalkyl-, N-phosphonoalkenyl-, and N...

[Bigge, Christopher F.; Johnson, Graham; Ortwine, Daniel F.; Drummond, James T.; Retz, Daniel M.; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 8 p. 1371 - 1384]

Une nouvelle voie d'acces aux indoles par condensation ylure...

[Corre, M. Le; Hercouet, A.; Stanc, Y. Le; Baron, H. Le Tetrahedron, 1985 , vol. 41, # 22 p. 5313 - 5320]