M 4 agonists/5HT 7 antagonists with potential as antischizophrenic drugs: Serominic compounds

…, H Yasumatsu, A McVie, LC Young, C McCraw…

Index: Suckling, Colin J.; Murphy, John A.; Khalaf, Abedawn I.; Zhou, Sheng-ze; Lizos, Dimitris E.; van Nhien, Albert Nguyen; Yasumatsu, Hiroshi; McVie, Allan; Young, Louise C.; McCraw, Corinna; Waterman, Peter G.; Morris, Brian J.; Pratt, Judith A.; Harvey, Alan L. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 9 p. 2649 - 2655

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Citation Number: 19

Abstract

Chronic low-dose treatment of rats with the psychomimetic drug, phencyclidine, induces regionally specific metabolic and neurochemical changes in the CNS that mirror those observed in the brains of schizophrenic patients. Recent evidence suggests that drugs targeting serotoninergic and muscarinic receptors, and in particular 5-HT7 antagonists and M4 agonists, exert beneficial effects in this model of schizophrenia. Compounds that ...