Tetrahedron

Solvent-free preparation of amides from acids and primary amines under microwave irradiation

L Perreux, A Loupy, F Volatron

Index: Perreux, Laurence; Loupy, Andre; Volatron, Francois Tetrahedron, 2002 , vol. 58, # 11 p. 2155 - 2162

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Citation Number: 170

Abstract

Synthesis of amides via pyrolysis of the salts obtained by mixing neat primary amines and carboxylic acids were realized under solvent-free conditions within short times and appreciable yields under microwave activation. The evident specific non-thermal microwave effects are attributed to polarity increase during the course of the reaction, due to development of a dipole in the transition state.