The need for better diuretic and hypotensive agents is attested by the extensive research effort which is being expended in these areas. Although a great variety of drugs is now available to the physician, most of these substances have severe limitations that impair their usefulness. Recently, derivatives of 1, 2, 4-benzothiadiazine I, 1-dioxide have been shown in experimental animals to be carbonic anhydrase inhibitors, and to produce marked One ...
