4H??1, 4??Benzothiazine, Dihydro??1, 4??benzothiazinones and 2??Amino??5??fluorobenzenethiol Derivatives: Design, Synthesis and in vitro Antimicrobial Screening

…, A Rosato, A Carrieri, F Corbo, C Franchini

Index: Armenise, Domenico; Muraglia, Marilena; Florio, Marco Antonio; De Laurentis, Nicolino; Rosato, Antonio; Carrieri, Antonio; Corbo, Filomena; Franchini, Carlo Archiv der Pharmazie, 2012 , vol. 345, # 5 p. 407 - 416

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Citation Number: 26

Abstract

Abstract As part of our studies focused on the design and synthesis of new antimicrobial agents a series of 7-fluoro-3, 4-dihydro-2H-1, 4-benzothiazine derivatives (4a–4f, 4h) and 7- fluoro-2H-1, 4-benzothiazin-3 (4H)-one analogues (4j–4o) were synthesized and evaluated for their in vitro inhibitory activity against a representative panel of Gram-positive and Gram- negative bacteria strains and also toward selected fungi species. These compounds were ...