Synthesis and biological activity of substituted 7-aza-8-aza (oxa)-bicyclo [4.3. 0]-6, 9-nonadienes

…, NA Vinogradova, VV Sorokin, AP Kriven'ko

Index: Smirnova, N. O.; Plotnikov, O. P.; Vinogradova, N. A.; Sorokin, V. V.; Kriven'ko, A. P. Pharmaceutical Chemistry Journal, 1995 , vol. 29, # 1 p. 49 - 50 Khimiko-Farmatsevticheskii Zhurnal, 1995 , vol. 29, # 1 p. 44 - 46

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Citation Number: 5

Abstract

Abstract Hydroxylamine-and hydrazine-induced heterocyclization of readily available 5- hydroxy-2.4-diacetyl-5-methyl-3R-cyclohexanones (R= methyl, phenyl, m-nitrophenyl, α- furyl) yielded 6-acetyl-5-hydroxy-5.9-dimethyl-7R-1-aza (oxa)-2-azabicyclo [4.3. 0]-2, 8- nonadienes (R= methyl, phenyl, m-nitrophenyl. α-furyl). The biological activity of the latter was tested using the Escherichia coli phage T 4, and was also tested on a stored ...