A switch in enantiomer preference between mitochondrial F 1 F 0-ATPase chemotypes

…, A Pudzianowski, H Monshizadegan, P Wang…

Index: Bisaha, Sharon N.; Malley, Mary F.; Pudzianowski, Andrew; Monshizadegan, Hossain; Wang, Paulina; Madsen, Cort S.; Gougoutas, Jack Z.; Stein, Philip D. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 11 p. 2749 - 2751

Full Text: HTML

Citation Number: 21

Abstract

The preferred absolute configuration of two series of F 1 F 0 -ATP synthase inhibitors was determined. Although the configuration of the active enantiomer in each series is different, each series presents the same 'triaryl' pharmacophore to the enzyme binding site. ... The preferred absolute configuration of two series of F 1 F 0 -ATP synthase inhibitors was determined. Although the configuration of the active enantiomer in each series is different, each series presents ...