8??Methyl??7??substituted??1, 6??naphthyridine??3??carboxylic acids as New 6??desfluoroquinolone antibacterials

…, V Cecchetti, O Tabarrini, A Fravolini

Index: Sabatini, Stefano; Cecchetti, Violetta; Tabarrini, Oriana; Fravolini, Arnaldo Journal of Heterocyclic Chemistry, 1999 , vol. 36, # 4 p. 953 - 957

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Citation Number: 7

Abstract

Abstract 1, 6-Naphthyridine-8-methyl-7-substituted-3-carboxylic acids were synthesized as new 6-desfluoro-quinolone antibacterials in which the usual fluorine atom at C-6 position was replaced by an endocyclic nitrogen atom. Comparing the antibacterial activity of these 6- azaquinolones with our previous 6-amino and 6-hydrogen counterparts, they resulted always less active. However, the presence of methyl group at C-8 position ensure good ...