Synthesis and biological activities of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, and its metabolically stable ether-linked analogues.

Y Suhara, H Takayama, S Nakane, T Miyashita…

Index: Suhara, Yoshitomo; Takayama, Hiroaki; Nakane, Shinji; Miyashita, Tomoyuki; Waku, Keizo; Sugiura, Takayuki Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 7 p. 903 - 907

Full Text: HTML

Citation Number: 36

Abstract

We synthesized 2-arachidonoylglycerol (1), an endogenous cannabinoid receptor ligand, and its metabolically stable ether-linked analogues. Compound 1 was synthesized from 1, 3- benzylideneglycerol (6) and arachidonic acid in the presence of N, N'- dicyclohexylcarbodiimide and 4-dimethylaminopyridine followed by treatment with boric acid and trimethyl borate. An ether-linked analogue of 2-arachidonoylglycerol (2) was ...