6-Acylamino-2-aminoquinolines as potent melanin-concentrating hormone 1 receptor antagonists. Identification, structure-activity relationship, and investigation of …

T Ulven, TM Frimurer, JM Receveur…

Index: Ulven, Trond; Frimurer, Thomas M.; Receveur, Jean-Marie; Little, Paul Brian; Rist, ystein; Norregaard, Pia K.; Hoegberg, Thomas Journal of Medicinal Chemistry, 2005 , vol. 48, # 18 p. 5684 - 5697

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Citation Number: 57

Abstract

Novel 6-acylamino-2-aminoquinoline melanin-concentrating hormone 1 receptor (MCH1R) antagonists were identified by sequential in silico screening with 3D pharmacophore models derived from a series of benzamide antagonists. The structure-activity relationship exploration by synthesis of analogues found structural demands around the western part of the compounds to be quite specific, whereas much structural freedom was found in the ...