The Journal of Organic Chemistry

The Synthesis of 5'-Deoxy-5'-S-(3-methylthiopropylamine) sulfoniumadenosine (“Decarboxylated S-Adenosylmethionine”)

GA Jamieson

Index: Jamieson,G.A. Journal of Organic Chemistry, 1963 , vol. 28, p. 2397 - 2400

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Citation Number: 25

Abstract

5 '-Deoxy-5'-S-(3-methylthiopropylamine) sulfoniumadenos~ ne, the biological precursor of spermidine, has been synthesized by the condensation of 2', 3'-isoprop~ lidene-5'-toluene-p- sulfonyladcnosine and 3-thiopropylamine followed by removal of the acetonide group and subsequent methylation of the thioether. The corresponding (2-methylthioethy1amine)-and (4-methylthiobuty1aniine) sulfoniun~ adenosine derivatives have been prepared in a ...