Design, synthesis, and SAR studies on a series of 2-pyridinylpiperazines as potent antagonists of the melanocortin-4 receptor

…, J Pontillo, BA Fleck, D Marinkovic, M Arellano…

Index: Tran, Joe A.; Pontillo, Joseph; Fleck, Beth A.; Marinkovic, Dragan; Arellano, Melissa; Tucci, Fabio C.; Lanier, Marion; Saunders, John; Jiang, Wanlong; Chen, Caroline W.; Foster, Alan C.; Chen, Chen Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 14 p. 3693 - 3696

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Citation Number: 4

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A series of 2-pyridinylpiperazines derived from β-Ala-(2,4-Cl)Phe dipeptide was synthesized for the study of their SARs and possible interactions with the MC4 receptor. Compounds such as 11k (K i = 6.5 nM) possessed high potency. ... We have previously demonstrated that the basic ...