e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Discovery and optimization of a novel series of thrombin receptor (par-1) antagonists: potent, selective peptide mimetics based on indole and indazole templates
Introduction. R-Thrombin is a key trypsin-like serine protease involved in coagulation and a variety of cellular actions, such as platelet aggregation, lymphocyte mitosis, monocyte chemotaxis, and endothelial cell proliferation. 1-4 Many of the effects of thrombin on cells are mediated by specific cell-surface receptors, which eluded identification for many years. However, in 1991, Coughlin and co-workers identified the first example of a thrombin ...
