Development of a Practical Synthesis of an Aminoindanol-Derived M1 Agonist†

…, SSK Borders, MT Clayton, PC Heath…

Index: Kozhushkov, Sergei I.; Yufit, Dmitrii S.; De Meijere, Armin Advanced Synthesis and Catalysis, 2005 , vol. 347, # 2-3 p. 255 - 265

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Citation Number: 11

Abstract

... product, Celite, and the black byproduct, were added methanol, H 2 O and (S)-(+)mandelic acid. ... Synthesis of Aniline 4 With a scaleable synthesis of enantiomerically enriched aminoindanol 7 in hand, we ... aniline 4 was soluble in DMF, if too much 10% Pd/C catalyst was used ...