Tetrahedron

Synthesis of 6h-pyrido [4, 3-b] carbazoles

SP Modi, T McComb, AH Zayed, RC Oglesby, S Archer

Index: Modi, Sandeep P.; McComb, Todd; Zayed, Abdel-Hadi; Oglesby, R. Christopher; Archer, Sydney Tetrahedron, 1990 , vol. 46, # 16 p. 5555 - 5562

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Citation Number: 12

Abstract

A few 6H-pyrido [4, 3-b] carbazoles were prepared for cytotoxicity testing in cultures of human lung cancer cells. Methyl 6-methoxyindoleacetate 13, prepared by reduction of methyl 4-(2-nitro-5-methoxyphenyl)-3-oxobutyrate 11, was condensed with 3-acetylpyridine to give the vinyl indole 14 which was quarternized with p-nitrobenzyl bromide. Cyclization of this salt with the aid of sodium methoxide and ethyl nicotinate methiodide gave the 6H- ...