l'lie cliscoi~ cry iii tlic aiidroatatie series that a C-;{osygeii sitbstitiiciit\ vas iiot an cssciitial prerecpisite of tiiological activity I-' Icd u:, to iiir-estigate" iioit-classical" aiidrostaiie structures in TI liicli the broader re-yiiircment of an elcctroii rich riiig. A was met hy tlw preseiicc of carboii-carlioii douhle Iioridb. In partic-ular it\ vas iioted that uusaturatioli at C-2 and ('-3 ill, or A3 olefiiis) wa:, compatiblc 11 itli a reasoiiahlc~ lc\-cl of biological activity.'[ti vie\ $* of the ...
