Isolation of a Major Metabolite (i-OHAP) of Aprindine and Its Identification as N-(3-(N, N-Diethylamino) propyl)-N-phenyl-2-aminoindan-5-ol.

M Shimizu, K Takatori, M KAJIWARA…

Index: Shimizu, Mikiko; Takatori, Kazuhiko; Kajiwara, Masahiro; Ogata, Hiroyasu Biological and Pharmaceutical Bulletin, 1998 , vol. 21, # 5 p. 530 - 534

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Citation Number: 7

Abstract

i-OHAP, a major metabolite of aprindine (AP), was isolated by TLC from rat feces and identified as N-[3-(N, N-diethylamino) propyl]-N-phenyl-2-aminoindan-5-ol, based on 1 H- NMR, the HH correlation spectroscopy (COSY) spectrum, MS and LC-MS. Its structure was also confirmed by comparison with the synthesized compound. The hydroxy group of i- OHAP was located at the 5-position of the indan ring. AP is a prochiral compound, and the ...