In vitro bioactivation of dihydrobenzoxathiin selective estrogen receptor modulators by cytochrome P450 3A4 in human liver microsomes: formation of reactive iminium …

…, M Silva Elipe, S Kim, JY Wu, F DiNinno…

Index: Kim, Seongkon; Wu, Jane Y; Chen, Helen Y; DiNinno, Frank Organic letters, 2003 , vol. 5, # 5 p. 685 - 688

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Citation Number: 46

Abstract

Estrogens and selective estrogen receptor modulators (SERMs) are prescribed widely in the clinic to alleviate symptoms in postmenopausal women, and they are metabolized to reactive intermediates, which may elicit adverse effects. As part of our efforts to develop