Synthesis, pharmacological characterization, and quantitative structure-activity relationship analyses of 3, 7, 9, 9-tetraalkylbispidines: Derivatives with specific …

U Schön, J Antel, R Brückner, J Messinger…

Index: Schoen, Uwe; Antel, Jochen; Brueckner, Reinhard; Messinger, Josef; Franke, Rainer; Gruska, Andreas Journal of Medicinal Chemistry, 1998 , vol. 41, # 3 p. 318 - 331

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Citation Number: 31

Abstract

A series of 3, 7, 9, 9-tetraalkyl-3, 7-diazabicyclo [3.3. 1] nonane derivatives (bispidines) was synthesized and identified as potential antiischemic agents. Pharmacological experiments in vitro as well as in vivo are described, and the results are listed. For selection of those compounds fitting best to the desired profile of a specific bradycardic antianginal agent decrease in heart rate without affecting contractility and blood pressure these results were ...