Tetrahedron

The application of Stille cross-coupling reactions with multiple nitrogen containing heterocycles

R Selig, D Schollmeyer, W Albrecht, S Laufer

Index: Selig, Roland; Schollmeyer, Dieter; Albrecht, Wolfgang; Laufer, Stefan Tetrahedron, 2011 , vol. 67, # 47 p. 9204 - 9213

Full Text: HTML

Citation Number: 5

Abstract

Substituted imidazoles and purine bioisosteres have been widely studied in the literature. We endeavored to combine these heterocyclic core structures into precursors, especially 7- azaindoles, of previously unknown pharmacologically relevant lead structures. A highly flexible synthetic procedure was developed, derived from investigations of the influence of the substrates, solvents, ligand systems, and side reactions.

~80%

Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, ...

[Mettey, Yvette; Gompel, Marie; Thomas, Virginie; Garnier, Matthieu; Leost, Maryse; Ceballos-Picot, Irene; Noble, Martin; Endicott, Jane; Vierfond, Jean-Michel; Meijer, Laurent Journal of Medicinal Chemistry, 2003 , vol. 46, # 2 p. 222 - 236]

Synthesis of 2-substituted-7-azaindoles from 2-amino-3-picol...

[Parcerisa, Javier; Romero, Manel; Pujol, Maria Dolors Tetrahedron, 2008 , vol. 64, # 3 p. 500 - 507]

Room-Temperature Transition-Metal-Free One-Pot Synthesis of ...

[Leboho, Tlabo C.; Van Vuuren, Sandy F.; Michael, Joseph P.; De Koning, Charles B. Organic and Biomolecular Chemistry, 2014 , vol. 12, # 2 p. 307 - 315]