Specific bradycardic agents. 2. Heteroaromatic modifications in the side chain of specific bradycardic benzazepinones: chemistry, pharmacology, and structure-activity …

…, M Reiffen, J Heider, M Psiorz, C Lillie

Index: Bomhard, Andreas; Reiffen, Manfred; Heider, Joachim; Psiorz, Manfred; Lillie, Christian Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 942 - 947

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Citation Number: 18

Abstract

Compound 1 (UL-FS 49) has recently been described as the representative of a novel class of antiischemic compounds termed" specific bradycardic agents". In search of specific bradycardic agents with different pharmacokinetic profiles, heteroaromatic analogues of 1 have been synthesized and evaluated for their bradycardic activity, selectivity, and duration of action. The chain length n and the nature of the heteroaromatic system of compounds 2 ...