Synthesis of novel pyrazole and dihydropyrazoles derivatives as potential anti-inflammatory and analgesic agents

NM Abd-El Gawad, HH Georgey, NA Ibrahim…

Index: Abd-El Gawad, Nagwa M.; Georgey, Hanan H.; Ibrahim, Nashwa A.; Amin, Noha H.; Abdelsalam, Rania M. Archives of Pharmacal Research, 2012 , vol. 35, # 5 p. 807 - 821

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Citation Number: 7

Abstract

Abstract Novel dihydropyrazole 5–8, 10 and pyrazole derivatives 12, 14, 15, 17 were synthesized. The structures of the newly synthesized compounds were elucidated by spectral and elemental analyses. The anti-inflammatory activity of all new compounds was evaluated using the carrageenan-induced rat paw edema test using indomethacin and celecoxib as reference drugs. The most active derivatives as anti-inflammatory agents ...