A Triple??Aldol Cascade Reaction for the Rapid Assembly of Polyketides

BJ Albert, H Yamamoto

Index: Albert, Brian J.; Yamamoto, Hisashi Angewandte Chemie - International Edition, 2010 , vol. 49, # 15 p. 2747 - 2749

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Citation Number: 60

Abstract

Polyketides have long provided synthetic organic chemists with a variety of complex architectures to construct and develop new chemical tools for, and provided medicine with, many useful drugs. About 1% of polyketides display drug activity, which is five times the average for natural products.[1] A common strategy in the synthesis of polyketides is the cross-aldol reaction, although it can be complicated by uncontrolled oligomerization and ...