Novel α-and β-amino acid inhibitors of influenza virus neuraminidase

…, WG Laver, W Kohlbrenner, DW Norbeck

Index: Kati; Montgomery; Maring; Stoll; Giranda; Chen; Laver; Kohlbrenner; Norbeck Antimicrobial Agents and Chemotherapy, 2001 , vol. 45, # 9 p. 2563 - 2570

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Citation Number: 45

Abstract

ABSTRACT In an effort to discover novel, noncarbohydrate inhibitors of influenza virus neuraminidase we hypothesized that compounds which contain positively charged amino groups in an appropriate position to interact with the Asp 152 or Tyr 406 side chains might be bound tightly by the enzyme. Testing of 300 α-and β-amino acids led to the discovery of two novel neuraminidase inhibitors, a phenylglycine and a pyrrolidine, which exhibited K i ...