Guests covering a range of polarities were examined for their ability to bind to a water- soluble cavitand and trigger its assembly into a supramolecular capsule. Specifically the guests examined were: tridecane 2, 1-dodecanol 3, 2-nonyloxy ethanol (ethylene glycol monononyl ether) 4, 2-(2-hexyloxyethoxy) ethanol (di (ethylene glycol) hexyl ether) 5, 2-[2-(2 propoxyethoxy) ethoxy] ethanol (tri (ethylene glycol) propyl ether) 6, and bis [2-(2- ...