Photochemical coupling of 5-bromouracil (BU) to a peptide linkage. A model for BU-DNA protein photocrosslinking

TM Dietz, RJ Von Trebra, BJ Swanson…

Index: Dietz, Timothy M.; Trebra, Robert J. von; Swanson, Barry J.; Koch, Tad H. Journal of the American Chemical Society, 1987 , vol. 109, # 6 p. 1793 - 1797

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Citation Number: 34

Abstract

Abstract: Photocrosslinking of DNA containing 5-bromouracil (BU) in place of some of the thymine to an associated protein has potential for studying protein nucleic acid interactions. Experiments with model compounds are described which indicate some of the electronic and molecular details of the crosslinking. Earlier experiments suggested that the BU chromophore in its r, r* singlet state reacted by C-Br bond homolysis probably leading to ...