ACE inhibitors hypothesis generation for selective design, synthesis and biological evaluation of 3-mercapto-2-methyl-propanoyl-pyrrolidine-3-imine derivatives as …

MAH Ismail, MN Aboul-Enein, KAM Abouzid…

Index: Ismail, Mohamed A.H.; Nabil Aboul-Enein; Abouzid, Khaled A.M.; Abou El Ella, Dalal A.; Ismail, Nasser S.M. Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 10 p. 3739 - 3746

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Citation Number: 12

Abstract

A series of new 3-mercapto-2-methyl-propanoyl-pyrrolidine derivatives (V, VIa–e) were designed. A new validated ACE inhibitors pharmacophore model (hypothesis) was generated for the first time in this research from the biologically active (frozen) conformation of Lisinopril–Human ACE complex that was downloaded from PDB, using stepwise technique of CATALYST modules. The molecular modeling compare–fit study of the ...