Thienotriazolodiazepines as platelet-activating factor antagonists. Steric limitations for the substituent in position 2

…, H Crowley, C Maresca, M O'Donnell

Index: Walser; Flynn; Mason; Crowley; Maresca; O'Donnell Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1440 - 1446

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Citation Number: 19

Abstract

(Method D). 1-(4-Aminophenyl) imidazole (44a) was accessible by reduction of the nitro compound as described in the literature.'The iodides 37 and 38 were obtained by iodination (Method F) of the dihydrobenzofurans 39 and 40: respectively (Scheme 111). The known 4- iOdO-isobutylben~ ene~(45d) was accessible by direct iodination of commercially available 46 with iodine monochloride. While the hydrogenation of the triple bond to the single bond ...