Tetrahedron: Asymmetry

A convenient method for the synthesis and resolution of Tröger base

S Satishkumar, M Periasamy

Index: Satishkumar, Sakilam; Periasamy, Mariappan Tetrahedron Asymmetry, 2006 , vol. 17, # 7 p. 1116 - 1119

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Citation Number: 37

Abstract

Tröger base 1, 1 a molecule containing chiral nitrogen centres exists in two enantiomeric forms. Due to its rigid and concave shape, it has attracted a large amount of research over the last several decades. 2 Its chiral nature was first identified by Prelog and Wieland in 1944. These authors separated the two enantiomers through chromatographic resolution on a d-lactose hydrate column followed by fractional crystallization. 3 Most of the hitherto reported methods of ...