Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)

…, L Lingardo, J Chapman, C Hwang, DR Alessi

Index: Pearce, Laura R.; Alton, Gordon R.; Richter, Daniel T.; Kath, John C.; Lingardo, Laura; Chapman, Justin; Hwang, Catherine; Alessi, Dario R. Biochemical Journal, 2010 , vol. 431, # 2 p. 245 - 255

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Citation Number: 130

Abstract

Abstract S6K1 (p70 ribosomal S6 kinase 1) is activated by insulin and growth factors via the PI3K (phosphoinositide 3-kinase) and mTOR (mammalian target of rapamycin) signalling pathways. S6K1 regulates numerous processes, such as protein synthesis, growth, proliferation and longevity, and its inhibition has been proposed as a strategy for the treatment of cancer and insulin resistance. In the present paper we describe a novel cell- ...