Functionalized pyrrolidines inhibit α-mannosidase activity and growth of human glioblastoma and melanoma cells

…, S Gerber-Lemaire, L Juillerat-Jeanneret

Index: Fiaux, Helene; Popowycz, Florence; Favre, Sylvain; Schuetz, Catherine; Vogel, Pierre; Gerber-Lemaire, Sandrine; Juillerat-Jeanneret, Lucienne Journal of Medicinal Chemistry, 2005 , vol. 48, # 13 p. 4237 - 4246

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Citation Number: 93

Abstract

New substituted pyrrolidine-3, 4-diol derivatives were prepared from d-(-)-and l-(+)-phenyl glycinol. The influence of the configuration and the substitution of the lateral side chain of these derivatives on the inhibition of 25 commercial glycosidases were determined.(2 R, 3 R, 4 S)-2-({[(1 R)-2-Hydroxy-1-phenylethyl] amino} methyl) pyrrolidine-3, 4-diol ((+)-7a) was a potent and selective inhibitor of jack bean α-mannosidase (K i= 135 nM). However, ...