N??hydroxysulfamides as analog of N??hydroxyurea: synthesis and biological evaluation

A Hajri, G Dewynter, M Criton, P Dilda…

Index: Hajri, A.-Houssem; Dewynter, Georges; Criton, Marc; Dilda, Pierre; Montero, Jean-Louis Heteroatom Chemistry, 2001 , vol. 12, # 1 p. 1 - 5

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Abstract

Abstract A series of sulfa‐ analog of hydroxyurea, derived from N‐ hydroxysulfamide H 2 NSO 2 NHOH, were synthesized starting from chlorosulfonyl isocyanate ( CSI) and O‐ substituted hydroxylamines. Their antiproliferative, antiviral ( in synergy with ddI), and antifungal activities have been evaluated. © 2001 John Wiley & Sons, Inc. Heteroatom Chem 12: 1– 5, ...