The Abramovitch adaption of the Fischer indole synthesis gave low yields of 7-fluoro-5- methoxytryptamine due in part to decomposition during the required decarboxylation step. Therefore, 7-fluoro-and 6, 7-difluoro-5-methoxytryptamines were prepared by reaction of aminobutyraldehyde (generated in situ from the diethyl acetal) with 2-fluoro-and 2, 3-difluoro- 4-methoxyphenylhydrazine, and the products converted to the corresponding serotonins. ...
