Enantiomerically pure (3'R)-and (3'S)-3', 4'-dihydrospiro [piperidine-2, 3'(2'H)-benzopyran] s (R)-10 and (S)-10 were successfully synthesized according to the CN (R, S) methodology with the aim of serving as a pattern for the generation of related spirocyclic compounds. Two different synthetic pathways were studied starting from 2-cyano-6-phenyloxazolopiperidine (- )-2. One of them was selected and used for the preparation of amines (R)-17 and (S)-17 ...
