Discovery of N-[4-[6-tert-Butyl-5-methoxy-8-(6-methoxy-2-oxo-1 H-pyridin-3-yl)-3-quinolyl] phenyl] methanesulfonamide (RG7109), a Potent Inhibitor of the Hepatitis C …

FX Talamas, SC Abbot, S Anand…

Index: Journal of Medicinal Chemistry, , vol. 57, # 5 p. 1914 - 1931

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Citation Number: 9

Abstract

... Journal of Medicinal Chemistry. ... Different chemotypes have been reported to bind in the palm I allosteric site. From those chemical classes, at least five compounds have entered clinical trials and some of them have shown efficacy. ...

… Butyl-5-methoxy-8-(6-methoxy-2-oxo-1 H-pyridin-3-yl)-3-qui...

[Talamas, Francisco X.; Abbot, Sarah C.; Anand, Shalini; Brameld, Ken A.; Carter, David S.; Chen, Jun; Davis, Dana; De Vicente, Javier; Fung, Amy D.; Gong, Leyi; Harris, Seth F.; Inbar, Petra; Labadie, Sharada S.; Lee, Eun K.; Lemoine, Remy; Le Pogam, Sophie; Leveque, Vincent; Li, Jim; McIntosh, Joel; Najera, Isabel; Park, Jaehyeon; Railkar, Aruna; Rajyaguru, Sonal; Sangi, Michael; Schoenfeld, Ryan C.; Staben, Leanna R.; Tan, Yunchou; Taygerly, Joshua P.; Villasenor, Armando G.; Weller, Paul E. Journal of Medicinal Chemistry, 2014 , vol. 57, # 5 p. 1914 - 1931]