ABSTRACT An efficient synthesis of 2-aminoestrone (14), 2-aminoestradiol (15), 2-amino- 16u-hydroxyestrone (16) and 2-amigestriol (17) is described. 2, 4-Dibromo estrogens L-4 were regiospecifically converted to the corresponding 2-nitro-4-bromo derivatives 5-8 in quantitative yields, with Zincke nitration using sodium nitrite. Catalytic hydrogenation of the 2- nitro-4-bromides 5-3 over palladium-on-charcoal gave directly the desired 2-amino ...
