The number of fluorinated organic molecules reported in the literature drastically increased over the past decades. 1 This infatuation is motivated by the fact that the introduction of fluorine atoms generally enhances the lipophilicity 2 —hence the bioavailability—of the molecule, and limits its degradation as the C–F bond is more stable than the almost isosteric C–H bond (480 vs 410 kJ mol −1 ). 3 Consequently, much effort is currently dedicated to the development of new ...
