A number of steroid analogs containing a hydrocarbon substituent at C-4 have been prepared by either or both of two methods. For one of these methods, direct alkylation of A4-- 3-keto-steroids, conditions are described which make it a useful preparative procedure. In the case of the second method, which involves treatment of an enol-lactone of a 5-oxo-3, 5- seco-A-nor acid with a Grignard reagent followed by base cyclization, the intermediate ...
