Synthetic studies on enkephalin analogs. I. Potent analgesic activity of H-Tyr-D-Ala-Gly-Phe-NHNH-CO-R (R= lower alkyl).

品川進， 藤野政彦， 石井治光， 川井清尚

Index: Shinagawa; Fujino; Ishii; Kawai Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 12 p. 3630 - 3638

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Abstract

... OMe[mp124一126°C, [z]常一18.0°(c=0.55,DMF}]with NH。NH。·H。O. 13)W,Königand R.Geiger,Chem.Ber,103。788(1970) 14)G.WoolfeandAD,Macdonald,J,Pharmacol.Exp,Ther。 80,300(1944), 15)K。Kawai,H.Ishi,T. Doi,S.Tamura。S.Shinagawa。and M.Fujino,Eur.J.Pha ...