Central nervous system active compounds. IV. Synthesis of 3-aminobenzylphthalides

GI Hutchison, PA Marshall, RH Prager, JM Tippett…

Index: Hutchison; Marshall; Prager; et al. Australian Journal of Chemistry, 1980 , vol. 33, # 12 p. 2699 - 2715

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Citation Number: 6

Abstract

Abstract Several 3-aminobenzylphthalides have been prepared by reactions of 3-(2-oxo-1- phenylpropyl)-phthalides with hydrazoic acid or by the Beckmann rearrangement. The corresponding reactions with 3-(2-oxoindanyl) phthalides showed limited success but led to a new synthesis of phthalide-isoquinoline alkaloids. Preliminary biological testing of some of these derivatives indicates that they only have weak central nervous system activity.

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