The Synthesis of Ethyl p-Nitrophenyl α-Acetoxyalkylphosphonates

…, JE Brown, MV Garrison, BH Alexander

Index: Hafner; Brown; Garrison; Alexander Journal of medicinal chemistry, 1965 , vol. 8, # 5 p. 730 - 731

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Citation Number: 4

Abstract

Method A. Butyl 4-(p-Iodobenzoyloxy) butyrate (21).--. I-) I-iiii't Iiylforni: iniide (400 nil.) which had been dried over silica gel W: IH pl: i (red in: I flask: tnd heated to llOo. With vigorous stirring 4! i.,-i p. i0. 1SX mole) of finely powdered sodiuni p-iodobenzoate w: tb: idded rapidlj- . In one portion 40.2 g.(0. IS0 mole) of hutyl4-I) roiiiiibiityr~ ile was added to the resulting suspension. Stirring: tiit1 lientiiig: it 105---115'were continued for 24 hr. The cooled iiiixture ...