Synthesis and biological evaluation of water-soluble 2-boronoethylthio compounds

DS Matteson, AH Soloway, DW Tomlinson…

Index: Matteson,D.S. et al. J. Med. Chem., 1964 , vol. 7, p. 640 - 643

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Citation Number: 33

Abstract

toxicity,\\ ei ('iouiid aiiioiig those borouic acids Iiaviiig a high water-lipid solwiit partition cocf1cient. 3'I) Thus a low lipid solubility sccined to he ail iiiipoitaiit rquirciiieiit for at~ oruii coiiipound.-1s cliiiical iiiforination Ixcaiiic available. it was apparcwt that thr probleiii was iiiorc iiivolvcd than the nicrc attniiiiiioiit of a high tuiiior braiii horoii ratio. Ht prcparatioii and clvaluatioii of a series of hi wlublc horoiiic acids pi'ewiit\\ ol-k oii t hr. ha Sy lit hc tic ii t hod-, ...