Bioorganic & medicinal chemistry

1-(1-Arylethylidene) thiosemicarbazide derivatives: A new class of tyrosinase inhibitors

J Liu, W Yi, Y Wan, L Ma, H Song

Index: Liu, Jinbing; Yi, Wei; Wan, Yiqian; Ma, Lin; Song, Huacan Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 3 p. 1096 - 1102

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Citation Number: 60

Abstract

A series of 1-(1-arylethylidene) thiosemicarbazide compounds and their analogues were synthesized and characterized by 1H NMR, MS. Their tyrosinase inhibitory activities were investigated by an assay based on the catalyzing ability of tyrosinase for the oxidation of l- DOPA, comparing with 4-methoxycinnamic acid and arbutin. The results showed that (1) all the synthesized compounds could perform a significant inhibitory activity for tyrosinase;(2) ...