For the preparation of 1, 5, 5-trialkylbarbituric acids two methods are available:(1) condensation of the dialkylmalonic ester with an alkylurea, and (2) direct alkylation of the 5, 5-dialkylbarbituric acid. The first of these procedures was used by Fischer and Dilthey'and subsequently extended by Dox and Hjoxt2 The second method was studied by Dox and Jonesa in the case of the more reactive halides such as benzyl chloride and allyl bromide, ...
