1-(4-Methoxyphenyl)-5-(3, 4, 5-trimethoxyphenyl)-1H-1, 2, 4-triazole-3-carboxamides: Synthesis, molecular modeling, evaluation of their anti-inflammatory activity and …

M Abdel-Aziz, EA Beshr, IM Abdel-Rahman…

Index: Abdel-Aziz, Mohamed; Beshr, Eman A.; Abdel-Rahman, Islam M.; Ozadali, Keriman; Tan, Oya Unsal; Aly, Omar M. European Journal of Medicinal Chemistry, 2014 , vol. 77, p. 155 - 165

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Citation Number: 4

Abstract

Abstract A series of novel 1-(4-methoxyphenyl)-5-(3, 4, 5-trimethoxyphenyl)-1H-1, 2, 4- triazole-3-carboxamides were synthesized and confirmed with different spectroscopic techniques. The prepared compounds exhibited remarkable anti-inflammatory activity that represents 38%–100% of indomethacin activity and 44%–115% of celecoxib activity after 3 h. The anilides 5a–l and hydrazide 6 exhibit low incidence of gastric ulceration compared ...