Exploring 9-benzyl purines as inhibitors of glutamate racemase (MurI) in Gram-positive bacteria

B Geng, G Breault, J Comita-Prevoir, R Petrichko…

Index: Geng, Bolin; Breault, Gloria; Comita-Prevoir, Janelle; Petrichko, Randy; Eyermann, Charles; Lundqvist, Tomas; Doig, Peter; Gorseth, Elise; Noonan, Brian Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 15 p. 4368 - 4372

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Citation Number: 15

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... An early SAR study of a screening hit series has generated a series of 9-benzyl purines as inhibitors of bacterial glutamate racemase (MurI) with micromolar enzyme potency and improved physical properties. X-ray co-crystal EI structures were obtained. ... An early SAR study of a ...