Total synthesis of camptothecin and desethyldesoxycamptothecin

AI Meyers, RL Nolen, EW Collington…

Index: Meyers; Nolen; Collington; et al. Journal of Organic Chemistry, 1973 , vol. 38, # 11 p. 1974 - 1982

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Citation Number: 50

Abstract

5 the hydroxy amide 6 to undergo a Michael addition at the a carbon to the amide group, the oxazine amide 7 was viewed as a plausible synthetic equivalent. The conversion of the oxazine ring to an aldehyde function and ultimately to a primary alcohol has already been demonstrated in previous synthetic efforts from this laboratory. 12 The preparation of 7 was accomplished in 85% yield by heating the readily available pyrrolo-[3, 4-b] quinoline 813 ...