Synthesis and antitumor activity of a series of ftorafur analogs: the effect of varying electronegativity at the 1'-position

MH Holshouser, AM Shipp…

Index: Holshouser, Mark H.; Shipp, Annette M.; Ferguson, Paul W. Journal of Medicinal Chemistry, 1985 , vol. 28, # 2 p. 242 - 245

Full Text: HTML

Citation Number: 6

Abstract

All the experiments were carried out under a nitrogen stream on capped vials. The anaerobic conditions were maintained with a disposable anaerobic indicator (Gas Pac Becton Dickinson Co., Orangeburg, NY). The incubations were carried out at 37 OC , and 4,8,16,24,72 h after the addition of the corresponding BA, the reaction was stopped with addition of 150 pL of a 30% solution of KOH. Tubes were centrifuged at 3500 rpm for 10 min, and 2 mL of the ...