The Journal of Organic Chemistry

5-Arylthiopyrimidines. II. 2-and 4-Alkylamino and 4-Amino Derivatives1

B ROTH, GH HITCHINGS

Index: Roth,B.; Hitchings,G.H. Journal of Organic Chemistry, 1961 , vol. 26, p. 2770 - 2778

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Citation Number: 12

Abstract

5-Bromoiaocytmine and Sbromouracil react readily with arylmercaptans in ethylene glycol at 150'to produce! &aryl-thiopyrimidinea in 4&50% yields. The 5-unsubstituted pyrimidines and the disulfide of the mercaptan are by-products of this reaction. 2-Amino-, zdislkylamine, and 2-mercapt~ 4-hydroxy-bsrylthiopyrimidines can also be prepared by the amdemation of guanidines or thiourea with a-alkoxymethylcnearylthioacetic esters. Chlorination and ...

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