Medicinal Chemistry Research

Design and synthesis of some thieno [2, 3-c] pyridazine derivatives of expected anticancer activity

AK El-Ansary, AM Kamal, MAH Al-Ghorafi

Index: El-Ansary, Afaf K.; Kamal, Aliaa M.; Al-Ghorafi, Mokhtar Abdhafiz Medicinal Chemistry Research, 2013 , vol. 22, # 6 p. 2589 - 2601

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Citation Number: 3

Abstract

Abstract Design and synthesis of some new thienopyridazine derivatives as anticancer agents were the goal of this work. Accordingly, a series of novel compounds were synthesized via reacting thienopyridazine carboxylic acid hydrazide with different organic reagents. Twelve novel compounds were selected by National Cancer Institute for a full anticancer screening assay where seven of the investigated compounds showed non- ...